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Review of ciprofloxacin use in children

N V Okoye1, M R Oyawole2, P U Uzochukwu2

  • 1Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, University of Lagos, Lagos, Nigeria. ngozikaokoye@yahoo.com

Nigerian Quarterly Journal of Hospital Medicine
|March 4, 2014
PubMed

Insights

Ciprofloxacin is frequently prescribed for children, often as a second-line treatment for severe infections. While adverse events occur, they are typically reversible and manageable, supporting its use when benefits outweigh risks.

Area of Science:

  • Pediatric Pharmacology
  • Infectious Disease Management

Background:

  • High frequency of ciprofloxacin prescriptions in pediatric populations noted.
  • Caution is advised for ciprofloxacin use in children, yet prescriptions remain common.

Purpose of the Study:

  • To determine the prescription frequency of ciprofloxacin in a pediatric unit.
  • To conduct a literature review on the use of ciprofloxacin in pediatric patients.

Main Methods:

  • Retrospective review of patient case notes in a pediatric general ward.
  • Systematic literature search of electronic databases (2001-2011) for relevant English-language articles.

Main Results:

  • Ciprofloxacin was prescribed for 20% of children in the preliminary study.
  • Literature indicates ciprofloxacin is used as second-line therapy for life-threatening infections with susceptible organisms.
  • Reported adverse events (arthralgia, GI, CNS) were reversible and often did not require treatment cessation.

Conclusions:

  • Ciprofloxacin can be considered for pediatric use as a second-line agent in severe, life-threatening infections.
  • Use is justified for susceptible organisms when the clinical benefit surpasses potential risks.
  • Careful patient monitoring for adverse events is essential.
Abstract

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