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Glioblastoma in elderly patients

Ian C Coulter1, Anil Varma, Philip J Kane

  • 1James Cook University Hospital, Middlesbrough, United Kingdom.

Journal of Neurosurgery
|March 4, 2014
PubMed
Summary

No abstract available in PubMed .

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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