Senescence and the pro-tumorigenic stroma.

Elise Alspach1, Yujie Fu2, Sheila A Stewart3

  • 1Department of Cell Biology and Physiology; BRIGHT Institute, Washington University School of Medicine, St. Louis, MO 63110.

Summary

Cellular senescence, a state of permanent growth arrest, has complex roles in cancer development. Initially thought to prevent tumors, it can also promote them, especially within the tumor microenvironment.

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