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A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay
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The Indian Consensus Document on cardiac biomarker

I Satyamurthy1, Jamshed J Dalal2, J P S Sawhney3

  • 1Director, Cardiology, Department of Cardiology at Apollo Hospitals, Chennai, India.

Indian Heart Journal
|March 4, 2014
PubMed

Insights

Diagnosing and managing heart failure remains challenging. Biomarkers offer valuable insights into heart failure (HF) severity and prognosis, potentially improving clinical assessments and patient outcomes.

Area of Science:

  • Cardiology
  • Biochemistry

Background:

  • Heart failure (HF) diagnosis and management present ongoing clinical challenges.
  • Common causes of congestive heart failure (CHF) in India include coronary artery disease, diabetes mellitus, and hypertension.
  • Recent advancements in understanding CHF pathophysiology have led to the evolution of biomarkers.

Framework:

  • Biomarkers in CHF reflect the extent of pathophysiological derangement.
  • Examples include markers of myocyte necrosis, myocardial remodeling, and neurohormonal activation.
  • Biomarkers indicate the presence, severity, and prognosis of CHF.

Implementation:

  • Biomarkers can be used alongside conventional clinical assessments.
  • They provide a feasible alternative to current expensive diagnostic measurements.
  • Integration of biomarkers may offer significant clinical benefits in HF management.

Implications:

  • Biomarkers enhance the diagnostic and prognostic capabilities in heart failure.
  • They offer a cost-effective approach to assessing disease severity.
  • Improved biomarker utilization can lead to better clinical decision-making and patient care.

Keywords:
BiomarkersBrain natriuretic peptideHeart failureNT-proBNP

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