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Myelin, myelination, and corresponding magnetic resonance imaging changes
Saurabh Guleria1, Teresa Gross Kelly2
1Pediatric Radiology, Children's of Alabama, University of Alabama at Birmingham, 1600 7th Avenue South, Lowder Building Ste. 306, Birmingham, AL 35233, USA.
Radiologic Clinics of North America
|March 4, 2014
Summary
Understanding white matter maturation is key for diagnosing related diseases. This review details the in vivo magnetic resonance (MR) appearance of myelination across brain regions and developmental stages.
Area of Science:
- Neuroimaging
- Developmental Neuroscience
- Radiology
Background:
- Accurate diagnosis of white matter diseases necessitates understanding white matter maturation.
- Maturation involves complex histologic and temporal developmental changes.
Purpose of the Study:
- To review the in vivo magnetic resonance (MR) appearance of myelination.
- To emphasize the MR appearance of different brain regions during development.
- To discuss useful MR pulse sequences for myelination stages.
Main Methods:
- Review of existing literature on white matter maturation and MR imaging.
- Analysis of MR imaging findings across various developmental time points.
- Correlation of histologic background with MR appearance.
Main Results:
- Detailed description of myelination patterns in vivo using MR.
- Emphasis on regional variations in white matter maturation.
- Identification of optimal MR pulse sequences for different developmental stages.
Conclusions:
- Understanding the MR appearance of myelination is crucial for diagnosing white matter diseases.
- MR imaging provides valuable insights into the dynamic process of brain development.
- Specific MR techniques aid in assessing myelination status at different ages.
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