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High urine IP-10 levels associate with chronic HCV infection
Linda Petrone1, Teresa Chiacchio1, Valentina Vanini1
1Translational Research Unit, Department of Epidemiology and Preclinical Research, "L. Spallanzani" National Institute for Infectious Diseases (INMI), IRCCS, 00149 Rome, Italy.
The Journal of Infection
|March 4, 2014
Summary
This study found increased levels of IP-10 in the urine of Hepatitis C virus (HCV)-viremic patients, suggesting urine IP-10 as a potential biomarker for HCV infection. This offers a novel non-invasive method for detecting the virus.
Area of Science:
- Hepatology
- Virology
- Biomarker Discovery
Background:
- Serum interferon-gamma-induced protein 10 (IP-10) is a known biomarker for predicting therapy response in chronic Hepatitis C virus (HCV) infection.
- Urine biomarkers for HCV infection have not been extensively evaluated, despite the potential of urine IP-10 in tuberculosis.
Purpose of the Study:
- To determine if IP-10 is detectable in the urine of chronically HCV-infected patients.
- To assess the correlation of urine IP-10 with serum IP-10 and HCV-specific clinical parameters.
Main Methods:
- Cross-sectional study involving 38 HCV-viremic patients, 10 cured-HCV subjects, and 11 healthy controls.
- Measurement of IP-10 in serum and urine using ELISA.
- Normalization of urine IP-10 levels with creatinuria.
Main Results:
- Measurable amounts of IP-10 were detected in the urine of HCV-viremic patients, though lower than in serum.
- The urine IP-10/creatinuria ratio was significantly higher in HCV-viremic patients compared to cured subjects and healthy donors.
- Urine IP-10/creatinuria ratio showed a low but significant correlation with transaminases.
Conclusions:
- IP-10 is detectable and increased in the urine of HCV-viremic patients compared to healthy and cured individuals.
- Urine IP-10, normalized with creatinuria, shows potential as a non-invasive biomarker for active HCV infection.
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