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Acute generalized exanthematous pustulosis caused by daptomycin in a critically ill burn victim

Hideharu Hagiya1, Maya Kimura, Toru Miyamoto

  • 1Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.

Internal Medicine (Tokyo, Japan)
|March 4, 2014
PubMed

Insights

Acute generalized exanthematous pustulosis (AGEP) is a drug reaction often caused by antibiotics. Daptomycin, an antibiotic for MRSA, can also trigger AGEP, complicating patient care.

Area of Science:

  • Dermatology
  • Infectious Diseases

Background:

  • Acute generalized exanthematous pustulosis (AGEP) is a rare, severe cutaneous adverse drug reaction.
  • It is typically a self-limiting condition, often triggered by antibiotics like penicillins and macrolides.

Observation:

  • A case study of a 77-year-old severe burn patient in an intensive care unit is presented.
  • The patient developed AGEP while undergoing treatment with daptomycin (DAP).

Findings:

  • Daptomycin (DAP), an antibiotic effective against methicillin-resistant Staphylococcus aureus (MRSA), was identified as the causative agent for AGEP in this patient.
  • This highlights a potential, albeit rare, adverse drug reaction associated with daptomycin use.

Implications:

  • Physicians should consider daptomycin as a potential cause of AGEP, especially in patients with severe infections and high fever.
  • Awareness of DAP-induced AGEP is crucial for managing patients in critical care settings and preventing diagnostic delays or misattributions of fever and inflammation.

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