Related Experiment Video

Updated: May 2, 2026

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
10:03

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

7.0K

[A case of colchicine-responsive Mollaret's meningitis with MEFV gene mutation]

Tomomi Kinohshita1, Akira Matsushima, Shunichi Satoh

  • 1Department of Neurology, Nagano Red-cross Hospital.

Rinsho Shinkeigaku = Clinical Neurology
|March 4, 2014
PubMed

Insights

Familial Mediterranean Fever (FMF) can cause recurrent meningitis. Colchicine therapy effectively prevented meningitis relapses in a patient with an MEFV gene mutation, suggesting its therapeutic potential.

Area of Science:

  • Neurology
  • Immunology
  • Genetics

Background:

  • Recurrent meningitis presents a diagnostic challenge, often unresponsive to standard treatments.
  • Mollaret's meningitis is characterized by recurrent aseptic meningitis with specific cerebrospinal fluid findings.

Observation:

  • A 66-year-old woman experienced 10 episodes of meningitis over 10 months.
  • Cerebrospinal fluid analysis revealed pleocytosis, Mollaret cells, and elevated IL-6 levels.
  • Initial antibiotic and antiviral treatments were unsuccessful in preventing relapse.

Findings:

  • Genetic testing identified a mutation in the MEFV gene, confirming Familial Mediterranean Fever (FMF).
  • Colchicine therapy demonstrated complete efficacy in preventing further meningitis recurrence.
  • The patient's presentation highlights the link between FMF and recurrent meningitis.

Implications:

  • Familial Mediterranean Fever (FMF) should be considered in the differential diagnosis of recurrent meningitis, particularly with Mollaret cells.
  • Neuro-Behçet's disease and neuro-Sweet disease are also important considerations for recurrent meningitis.
  • Colchicine therapy offers a promising treatment strategy for meningitis relapses associated with FMF.

More Related Videos

Protein-tRNA Agarose Gel Retardation Assays for the Analysis of the N6-threonylcarbamoyladenosine TcdA Function08:03

Protein-tRNA Agarose Gel Retardation Assays for the Analysis of the N6-threonylcarbamoyladenosine TcdA Function

Published on: June 21, 2017

9.6K
Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing07:24

Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing

Published on: February 10, 2023

2.0K

Related Concept Videos

Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
24
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
15
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
199
Mutations in Microorganisms01:18

Mutations in Microorganisms

Mutations are heritable changes in an organism’s genome involving alterations in the base sequence of DNA or RNA. These changes can influence cellular processes and phenotypic traits, potentially transforming the unaltered wild type into a mutant form. Such changes, termed forward mutations, are pivotal in shaping the genetic diversity of organisms.RNA viruses exhibit the highest mutation rates due to the absence of robust proofreading mechanisms during genome replication. In contrast,...
1.2K
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
102
Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
5.4K