Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Diabetes Insipidus II: Pathophysiology

Diabetes Insipidus II: Pathophysiology

Normally, water balance is maintained through three interconnected mechanisms: the hypothalamic thirst center, the synthesis and release of antidiuretic hormone (ADH, or vasopressin), and the kidneys' responsiveness to this hormone. ADH is synthesized in the hypothalamus, released from the posterior pituitary, and acts on the distal nephron, allowing water reabsorption and concentrated urine production.Diabetes Insipidus and Its TypesIn diabetes insipidus (DI), this regulatory system is...

Hormonal Regulation of Blood Pressure

Hormonal Regulation of Blood Pressure

Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...

Physiology of the Genitourinary System III: Urine Concentration and Dilution

Physiology of the Genitourinary System III: Urine Concentration and Dilution

The kidneys concentrate or dilute urine to maintain water and electrolyte balance. Nephrons, particularly the loop of Henle, play a crucial role in this process through the countercurrent multiplication system. This system establishes a high osmolarity in the renal medulla, which is essential for water reabsorption. In the loop of Henle’s descending limb, water is reabsorbed into the surrounding medulla due to its permeability to water. In contrast, the ascending limb actively transports...

Hormonal Regulation

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.

Diabetes Insipidus I: Introduction

Diabetes Insipidus I: Introduction

Definition Diabetes insipidus is a disorder marked by the production of large amounts of dilute urine because of impaired vasopressin production, release, or kidney response. The lack of effective vasopressin action limits water reabsorption in the renal collecting ducts, which leads to excessive urinary water loss and intense thirst.Clinical PresentationIndividuals with diabetes insipidus report persistent thirst and very high urine output. In severe cases, fluid intake can reach up to 20...

Regulation of Water Output

Regulation of Water Output

The human body predominantly expels water through the urinary system. On average, an individual generates around 1.5 liters of urine each day. This amount can fluctuate based on how well a person is hydrated, but a critical minimum quantity of urine must be produced to ensure the body's proper functioning. Daily, the kidneys remove 600 to 1200 milliosmoles of dissolved substances, effectively excreting excess minerals and water-soluble toxins such as creatinine, urea, and uric acid from the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Management of cirrhotic ascites in children: Review and recommendations. Part 2: Electrolyte disturbances, nonelectrolyte disturbances, therapeutic options.

Archivos argentinos de pediatria·2017

Same author

Management of cirrhotic ascites in children. Review and recommendations. Part 1: Pathophysiology, diagnostic evaluation, hospitalization criteria, treatment, nutritional management.

Archivos argentinos de pediatria·2017

Same author

Ouabain Protects Human Renal Cells against the Cytotoxic Effects of Shiga Toxin Type 2 and Subtilase Cytotoxin.

Toxins·2017

Same author

Effects of shiga toxin 2 on cellular regeneration mechanisms in primary and three-dimensional cultures of human renal tubular epithelial cells.

Microbial pathogenesis·2016

Same author

Prevention of renal damage caused by Shiga toxin type 2: Action of Miglustat on human endothelial and epithelial cells.

Toxicon : official journal of the International Society on Toxinology·2015

Same author

TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization.

The Journal of clinical investigation·2015

Same journal

Vesicoureteral reflux in children with urinary tract infections caused by atypical pathogens: Diagnostic accuracy of renal ultrasound.

Archivos argentinos de pediatria·2026

Same journal

The DOHaD concept: Advances and challenges ten years after its inclusion in the pediatric agenda.

Archivos argentinos de pediatria·2026

Same journal

Malnutrition and hypernatremic dehydration as the initial presentation of nephrogenic diabetes insipidus in an infant.

Archivos argentinos de pediatria·2026

Same journal

Biologic therapies in pediatric psoriasis: A single-center experience.

Archivos argentinos de pediatria·2026

Same journal

School violence: An oxymoron.

Archivos argentinos de pediatria·2026

Same journal

Toward a new paradigm in kidney care: An urgent need.

Archivos argentinos de pediatria·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 2, 2026

Culturing Primary Rat Inner Medullary Collecting Duct Cells

Culturing Primary Rat Inner Medullary Collecting Duct Cells

Published on: June 21, 2013

[Antidiuretic hormone, 2014]

Horacio A Repetto¹

¹Hospital Nacional Prof. A. Posadas.

Archivos Argentinos De Pediatria

|March 4, 2014

Summary

No abstract available in PubMed .

More Related Videos

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells

Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells

Published on: March 5, 2019

Related Experiment Videos

Last Updated: May 2, 2026

Culturing Primary Rat Inner Medullary Collecting Duct Cells

Culturing Primary Rat Inner Medullary Collecting Duct Cells

Published on: June 21, 2013

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells

Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells

Published on: March 5, 2019