Simplified first-trimester fetal cardiac screening (four chamber view and ventricular outflow tracts) in a low-risk...

Our aim was to assess the accuracy of a simplified fetal cardiac study, inclusive of four-chamber view (4CV) and ventricular outflow tracts, performed during the 11-14 week screening by well-trained obstetricians to detect congenital heart diseases (CHDs).

A transabdominal ultrasound was performed on 4820 singleton pregnant women at 11-14 weeks to visualize the visceral site, the 4CV, and the outflow tracts. Neonatal outcomes were recorded 6 and 12 months after birth.

Among the 4820 patients reviewed, 790 were excluded because of loss at prenatal or postnatal follow-up (649 cases), or inability to obtain adequate first-trimester sonographic cardiac evaluation (141 cases). Among the 4030 included cases, 32 CHD cases were detected (20 major and 12 minor); 18 of the major (90%) and five of the minor (42%) were detected or suspected in the first trimester, one major and six minor in the second trimester, and one major and one minor only after birth.

A simplified protocol is an effective tool to screen for CHD at 11-14 weeks.