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Angiogenesis induction by CD-4 positive lymphocytes

M Kaminski1, R Auerbach

  • 1Laboratory of Developmental Biology, University of Wisconsin, Madison 53706.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
|September 1, 1988
PubMed

Adult splenocytes from BALB/c mice, labeled with a monoclonal antibody directed against the L3T4 (CD-4) differentiation antigen, were sorted to obtain pure suspensions of this T-cell subset. When inoculated intradermally into irradiated, semi-allogeneic adult animals these cells were found to be the effector cells responsible for the lymphocyte-induced angiogenesis. The experiments demonstrate that the CD-4 lymphocyte subset is primarily or entirely responsible for this immune-mediated elicitation of the host neovascular reaction.

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