Adjuvant effect of DEAE-dextran on cholera vaccines
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1Human Institute for Serobacteriological Production and Research, WHO Collaborating Centre for Reference and Research on Bacterial Vaccines, Budapest, Hungary.
Vaccine
|June 1, 1988
Abstract:
Investigations into the effectiveness of DEAE-dextran as an adjuvant of whole cell cholera vaccines (Vibrio cholerae Inaba and Ogawa serotypes) were conducted using two methods: (a) the active mouse protection test, (b) the determination of antibody production in the sera of immunized mice by measuring the level of vibriocidal antibodies, and by an enzyme-linked immunosorbent assay (ELISA). In all tests, the DEAE-dextran-adjuvanted vaccine showed an antigenicity substantially superior to that achieved without adjuvants.