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Updated: May 2, 2026
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The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
Published on: November 19, 2008
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Association between hypoxia and perinatal arterial ischemic stroke: a meta-analysis
Lili Luo1, Dapeng Chen2, Yi Qu3
1Department of Pediatrics, West China Second University Hospital, Sichuan University, Sichuan, China ; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan University, Sichuan, China ; Department of Emergency, West China Second University Hospital, Sichuan University, Sichuan, China.
Plos One
|March 4, 2014
Summary
Perinatal hypoxia factors are significantly associated with perinatal arterial ischemic stroke (AIS). This meta-analysis suggests hypoxia may be a cause of AIS, warranting further large-scale studies.
Area of Science:
- Neonatal Neurology
- Perinatal Medicine
- Epidemiology
Background:
- Perinatal arterial ischemic stroke (AIS) affects 17-93 per 100,000 live births.
- The etiology of AIS is not well understood, with ongoing debate regarding the role of hypoxia.
- This study aimed to clarify the association between perinatal hypoxia and AIS.
Purpose of the Study:
- To conduct a meta-analysis of observational studies.
- To estimate the association between perinatal hypoxia factors and perinatal AIS.
- To provide evidence for the role of hypoxia in AIS etiology.
Main Methods:
- Systematic literature search up to July 2013.
- Inclusion of 8 observational studies with 550 newborns diagnosed with AIS.
- Meta-analysis using fixed-effects or random-effects models to calculate odds ratios (ORs) and 95% confidence intervals (CIs).
Main Results:
- Significant associations found between AIS and preeclampsia (OR 2.14), ventouse delivery (OR 2.23), fetal heart rate abnormalities (OR 6.30), reduced fetal movement (OR 5.35), meconium-stained liquor (OR 3.05), low Apgar score (OR 5.77), and resuscitation at birth (OR 4.59).
- No significant association was found for oxytocin induction (OR 1.33).
- A significant association was noted for low arterial umbilical cord pH (OR 4.63).
Conclusions:
- Perinatal hypoxia factors are significantly associated with perinatal arterial ischemic stroke (AIS).
- The findings support the hypothesis that perinatal hypoxia is a contributing factor to AIS.
- Further large-scale prospective clinical studies are recommended to confirm these associations.
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