Related Experiment Video

Updated: May 2, 2026

In vitro Method to Observe E-selectin-mediated Interactions Between Prostate Circulating Tumor Cells Derived From Patients and Human Endothelial Cells
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Cellular adhesion and the endothelium: P-selectin

Abdullah Kutlar1, Stephen H Embury2

  • 1Sickle Cell Center, Department of Medicine, Georgia Regents University, 1120 15th Street, Augusta, GA 30912, USA.

Hematology/Oncology Clinics of North America
|March 5, 2014
PubMed

P-selectin on endothelial cell surfaces is central to impaired microvascular blood flow in sickle cell disease (SCD). Restoration of blood flow is expected to provide therapeutic benefit for SCD patients, whatever the mechanism of action of the treatment. Long-term oral administration of a P-selectin-blocking agent potentially improves blood flow and averts acute painful vaso-occlusive crises in patients with SCD. This review focuses on the pathophysiology of the impairment of microvascular blood flow in SCD with an emphasis on the role of P-selectin and summarizes the status of development of antiselectin therapies as a means of improving microvascular flow.

Keywords:
Impaired blood flow in sickle cell diseaseMicrovascular occlusionP-selectinPentosan polysulfate sodiumSickle cell diseaseSickle red cell adhesion

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