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Thrombin induces endothelium-dependent relaxation of pig coronary arteries
1Institute of Pharmacology and Toxicology, Medical Academy Erfurt, GDR.
Folia Haematologica (Leipzig, Germany : 1928)
|January 1, 1988
Abstract:
At nanomolar concentrations, the proteolytic enzyme thrombin caused a reversible concentration-dependent relaxation of PGF2 alpha-precontracted pig coronary artery ring segments with intact endothelium. After mechanical removal of the endothelium both thrombin- and bradykinin-induced relaxation disappeared. The thrombin-induced relaxation was inhibited by the tightbinding inhibitor hirudin in a concentration-dependent manner.