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Related Experiment Video

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Author Spotlight: A Non-Invasive Tool to Assess and Differentiate Fat Patterns in Liver Using 3D Dixon MRI
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Hepatic fat during fasting and refeeding by MRI fat quantification.

Sreenath Narayan1, Chris A Flask, Satish C Kalhan

  • 1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.

Journal of Magnetic Resonance Imaging : JMRI
|March 5, 2014
PubMed
Summary

High-field small animal MRI accurately detects dynamic liver fat changes. Fasting increased hepatic fat, which reversed upon refeeding, demonstrating MRI

Keywords:
fasting refeedinghepatic fat prandial statein vivo mouse imaging

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Area of Science:

  • Biomedical Imaging
  • Magnetic Resonance Imaging
  • Hepatic Metabolism

Background:

  • Hepatic fat content is a key indicator of metabolic health.
  • Accurate, non-invasive methods are needed to monitor dynamic changes in liver fat.

Purpose of the Study:

  • To assess the sensitivity of high-field small animal MRI to dynamic changes in liver fat.
  • To investigate the influence of prandial state on hepatic fat imaging.

Main Methods:

  • Asymmetric spin-echo MRI sequences were used to acquire data at three timepoints over 48 hours.
  • Mice were subjected to a fasting/refeeding protocol to induce dynamic changes in hepatic fat.
  • Fat fraction maps were generated, and regions of interest in the liver were analyzed over time.

Main Results:

  • Five of six fasted mice showed a significant increase in hepatic fat fraction (average 0.54 ± 0.48).
  • Refeeding led to a decrease in hepatic fat fraction.
  • Statistical analysis confirmed significant effects of both fasting/refeeding and time on liver fat content (P = 0.003).

Conclusions:

  • Fat-water MRI techniques are sensitive to short-term dietary-induced alterations in hepatic fat.
  • MRI can reliably quantify dynamic changes in liver fat content in small animal models.