Living with HIV and growing old.

Area of Science:

• Gerontology
• Infectious Diseases
• Public Health

Background:

• Advances in antiretroviral therapy (ART) have transformed HIV from a terminal illness into a chronic condition.
• People living with HIV (PLWH) are now experiencing aging, presenting unique health challenges.
• The long-term effects of HIV and ART on aging are not fully understood.

Purpose of the Study:

• To explore the multifaceted challenges faced by aging individuals living with HIV.
• To identify key areas for research and clinical intervention in geriatric HIV care.
• To highlight the need for comprehensive strategies addressing the comorbidities and psychosocial aspects of aging with HIV.

Main Methods:

• Systematic literature review of studies on aging and HIV.
• Analysis of epidemiological data on the health status of older PLWH.
• Qualitative research exploring the lived experiences of aging with HIV.

Main Results:

• Older PLWH exhibit higher rates of age-associated comorbidities (e.g., cardiovascular disease, neurocognitive decline, osteoporosis).
• Long-term exposure to ART may contribute to specific toxicities and health issues.
• Psychosocial challenges, including social isolation and stigma, are amplified in aging PLWH.

Conclusions:

• Aging with HIV presents a complex interplay of biological, clinical, and psychosocial factors.
• Integrated care models are essential to manage comorbidities and improve quality of life for aging PLWH.
• Further research is needed to optimize long-term management and support for this growing population.