Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Human induced pluripotent stem cell cardiomyocytes for risk stratification of patients with LQT syndrome - ready for practice?

Cardiovascular research·2026

Same author

Mechanical load inhibits cancer growth in mouse and human hearts.

Science (New York, N.Y.)·2026

Same author

Models of the human heart for biomedical research: Opportunities and challenges.

Physiological reports·2026

Same author

Diversity-in-a-dish: A practical framework for hiPSC model development.

Stem cell reports·2026

Same author

Simtuzumab Attenuates Loxl2-Mediated Extracellular Matrix Remodeling and Preserves Cardiac Function in <i>LMNA</i> Mutation-Induced Dilated Cardiomyopathy.

Circulation. Heart failure·2026

Same author

Activation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure.

Nature communications·2026

Same journal

The Biology of Malaria Parasite Liver Infection.

Cold Spring Harbor perspectives in medicine·2026

Same journal

The Interaction between Diabetes Mellitus and Tuberculosis: Epidemiology, Screening, and Clinical Management.

Cold Spring Harbor perspectives in medicine·2026

Same journal

New Malaria Prevention Modalities: Long-Acting Interventions Beyond Vaccines.

Cold Spring Harbor perspectives in medicine·2026

Same journal

From Parasite to Pill: Harnessing Biology for Breakthroughs in Antimalarial Drug Discovery.

Cold Spring Harbor perspectives in medicine·2026

Same journal

Malaria Parasite Genomics: Decentralization, Diversification, and Development Goals.

Cold Spring Harbor perspectives in medicine·2026

Same journal

Tuberculosis Infection: Diagnosis and Management.

Cold Spring Harbor perspectives in medicine·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 2, 2026

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

Myocardial tissue engineering: in vitro models.

Gordana Vunjak Novakovic¹, Thomas Eschenhagen, Christine Mummery

¹Mikati Foundation Mikati Foundation, Columbia University, New York, NewYork 10032.

Cold Spring Harbor Perspectives in Medicine

|March 5, 2014

Summary

This summary is machine-generated.

Engineered human heart tissue models offer a new way to study heart function and test drugs. These advanced in vitro models improve drug screening and disease prediction.

More Related Videos

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Published on: March 14, 2021

Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues

Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues

Published on: June 2, 2023

Related Experiment Videos

Last Updated: May 2, 2026

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

Published on: March 14, 2021

Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues

Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues

Published on: June 2, 2023

Area of Science:

Biomedical Engineering
Cardiovascular Research
Tissue Engineering

Background:

Integrated human physiology modeling in vitro remains a significant challenge.
Tissue engineering advances enable authentic representation of tissue development and disease.
Functional human tissue units promise to revolutionize drug screening and disease modeling.

Purpose of the Study:

To review the in vitro engineering of functional human myocardium.
To highlight applications in myocardial function analysis.
To discuss utility in physiological studies, drug screening, and safety pharmacology.

Main Methods:

Focus on tissue engineering approaches for myocardium creation.
Emphasis on achieving biological fidelity in engineered tissues.
Integration of high-throughput screening and real-time physiological measurements.

Main Results:

Engineered myocardium mimics native heart tissue for functional analysis.
These models provide real-time insights into morphogenic events.
Potential for accurate prediction of therapeutic and toxicological effects.

Conclusions:

In vitro engineered human myocardium is a powerful tool for research.
These models can significantly advance drug discovery and safety assessment.
Tissue engineering is transforming predictive modeling of cardiovascular disease.