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Diversity-in-a-dish: A practical framework for hiPSC model development.

Jesse Weidema1, Hanna Lammertse2, Martine de Vries1

  • 1Department of Medical Ethics and Health Law, Leiden University Medical Center, Leiden, the Netherlands.

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Summary
This summary is machine-generated.

This study provides guidance for incorporating human induced pluripotent stem cell (hiPSC) diversity in research. It offers recommendations and a decision framework to improve transparency and reproducibility in stem cell studies.

Keywords:
diversityhuman induced pluripotent stem cellsmodel validationorgan-on-chiporganoidpreclinical research

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Area of Science:

  • Stem Cell Biology
  • Genomics
  • Biomedical Research

Background:

  • Human induced pluripotent stem cell (hiPSC) models exhibit donor-specific variations impacting experimental results and generalizability.
  • While diversity is a key consideration in genomics and biomedical research, specific guidance for hiPSC research is lacking.

Purpose of the Study:

  • To extend existing genomics frameworks to create stem cell-specific recommendations for diversity reporting in hiPSC research.
  • To introduce a decision framework to guide the incorporation of diversity in hiPSC-based studies.
  • To promote transparent and reproducible diversity-related design and reporting in the field.

Main Methods:

  • Extending genomics frameworks for stem cell applications.
  • Developing a decision framework with criteria including experimental purpose, biological plausibility, platform readiness, and statistical power.
  • Providing recommendations for describing and reporting diversity in hiPSC research.

Main Results:

  • Stem cell-specific recommendations for describing and reporting diversity.
  • A practical decision framework to determine the appropriate incorporation of diversity in hiPSC research.
  • A basis for enhanced transparency and reproducibility in diversity-related aspects of hiPSC studies.

Conclusions:

  • Addressing donor-specific variation in hiPSC models is crucial for robust and generalizable research outcomes.
  • The proposed framework and recommendations facilitate informed decisions regarding diversity in hiPSC research design and reporting.
  • Implementing these guidelines will contribute to more transparent, reproducible, and scientifically rigorous stem cell research.