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Different profile of serum leptin between early onset and late onset preeclampsia
Saeedeh Salimi1, Farzaneh Farajian-Mashhadi2, Anoosh Naghavi3
1Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran ; Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran.
Insights
Serum leptin and adiponectin are elevated in preeclampsia (PE). Leptin levels can help differentiate early-onset PE from late-onset PE and correlate with disease severity and BMI.
Area of Science:
- Reproductive Endocrinology
- Metabolic Disorders
- Maternal-Fetal Medicine
Background:
- Preeclampsia (PE) is a serious pregnancy complication.
- The roles of leptin and adiponectin in PE pathogenesis require further clarification.
Purpose of the Study:
- To investigate the association of leptin and adiponectin with preeclampsia.
- To explore the potential of these adipokines as biomarkers for PE subtypes and severity.
Main Methods:
- A case-control study involving 45 PE patients and 45 healthy controls.
- Serum leptin and adiponectin levels were measured using ELISA.
- Analysis included comparisons between PE subtypes (early-onset vs. late-onset) and severity (mild vs. severe).
Main Results:
- Serum leptin and adiponectin levels were significantly higher in PE patients compared to controls.
- Leptin was elevated in both early-onset PE (EOPE) and late-onset PE (LOPE), and higher in EOPE than LOPE.
- Leptin levels correlated positively with BMI in controls and with disease severity in PE patients.
Conclusions:
- Serum leptin may serve as a valuable biomarker for distinguishing between early and late-onset PE.
- Leptin levels are associated with PE severity and BMI.
- Adiponectin levels were elevated in severe PE but did not differ between EOPE and LOPE.
Aim:
This study was designed to clarify the role of leptin and adiponectin in preeclampsia (PE) pathogenesis and different subtypes of preeclampsia.
Method:
This case control study was performed in 45 PE patients and 45 healthy controls matched for age, BMI, and ethnicity. Serum leptin and adiponectin levels were determined by enzyme linked immunosorbent assay (ELISA).
Results:
Maternal serum leptin and adiponectin were significantly higher in PE women than controls. Serum leptin was elevated in early onset preeclampsia (EOPE) and late onset preeclampsia (LOPE) compared to controls. Among PE patients, serum leptin was higher in EOPE than LOPE women. However, serum adiponectin was not different between EOPE and LOPE women. The serum leptin was significantly higher in severe PE than mild PE. The serum adiponectin was significantly elevated in severe PE compared to controls. Significant positive correlation was observed between leptin and adiponectin and also between leptin and BMI in controls. Moreover significant positive correlation was observed between adiponectin and BMI in PE patients and controls.
Conclusion:
The present study showed that serum leptin level may play a significant role as a biomarker to differentiate early and late onset PE and also its relation to BMI and severity of disease.
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