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Prostate biopsy sampling causes hematogenous dissemination of epithelial cellular material
Sam Ladjevardi1, Gert Auer2, Juan Castro3
1Surgical Science, Uppsala University, 751 85 Uppsala, Sweden.
Disease Markers
|March 5, 2014
Summary
Diagnostic prostate cancer biopsies significantly increase epithelial cellular material (ECM) in blood, indicating a risk of cancer cell spread. Further research is needed to understand the implications of this finding.
Area of Science:
- Oncology
- Pathology
- Medical Diagnostics
Background:
- Core needle biopsy (CNB) is a common diagnostic tool for prostate cancer.
- The potential for cancer cell dissemination following invasive procedures is a significant concern in oncology.
Purpose of the Study:
- To investigate the presence and extent of epithelial cellular material (ECM) in peripheral blood after prostate cancer diagnostic core needle biopsy (CNB).
- To assess the risk of cancer cell dissemination associated with CNB procedures.
Main Methods:
- Peripheral blood samples were collected from 23 prostate cancer patients and 15 control patients before and after a series of 10 CNB procedures.
- Quantification of epithelial cellular material (ECM) in blood samples was performed.
Main Results:
- A significant increase in ECM was observed in blood samples taken 20 seconds and 30 minutes after the final CNB, compared to pre-biopsy levels.
- The study involved patients diagnosed with prostate cancer via CNB and a control group without cancer.
Conclusions:
- Diagnostic CNB for prostate cancer induces substantial tissue trauma.
- The findings suggest a potential risk of cancer cell dissemination into the bloodstream following CNB.
