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Updated: May 2, 2026
10:01
Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
Published on: July 10, 2012
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Pneumonia in solid organ transplant recipients: a prospective multicenter study.
M Giannella1, P Muñoz, J M Alarcón
1Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañon, Madrid, Spain; CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
Summary
Pneumonia is common in solid organ transplant (SOT) recipients, but often occurs later and with less severe outcomes than previously believed. This study investigated its epidemiology, diagnosis, treatment, and outcomes in a broad SOT population.
Area of Science:
- Solid organ transplantation
- Infectious diseases
- Pulmonology
Background:
- Pneumonia poses significant risks to solid organ transplant (SOT) recipients, contributing to high morbidity and mortality.
- Existing research on SOT pneumonia is limited, often retrospective, single-center, or focused on specific transplant types or causes.
Purpose of the Study:
- To investigate the epidemiology, diagnosis, therapy, and outcomes of pneumonia in an unselected population of SOT recipients.
- To provide a comprehensive overview of pneumonia in SOT patients through a point prevalence study.
Main Methods:
- A point prevalence study involving Italian and Spanish transplant centers.
- Data collection on SOT recipients with pneumonia treated during two separate weeks in February and June 2012.
Main Results:
- The incidence of pneumonia was 10.1 episodes/1000 recipients/year, with 70.4% classified as late-onset.
- Bacterial infections were most common (87.1%), with multidrug-resistant bacteria increasing in healthcare-associated and hospital-acquired pneumonia.
- While 11.1% of patients required intensive care, in-hospital mortality was low at 1.9%.
Conclusions:
- Pneumonia is a frequent complication in SOT recipients, typically occurring later in the post-transplant course.
- Despite its frequency, pneumonia in SOT recipients may be associated with less severe pathogens and better outcomes than previously suggested.
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