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[Serodiagnosis: tumor marker]
M Yoneshima1, N Hattori, N Sawabu
11st Dept. of Internal Medicine, School of Med. Kanazawa Univ.
Gan No Rinsho. Japan Journal of Cancer Clinics
|August 1, 1988
Summary
Tumor marker research, starting in 1848, aims for earlier cancer detection. Advances include new markers and improved assays for diagnosing cancer and precancerous states.
Area of Science:
- Biochemistry
- Oncology
- Immunology
Context:
- The historical development of tumor marker research dates back to Bence Jones protein in 1848.
- Current popular tumor markers include alpha-fetoprotein and carcinoembryonic antigen.
- Recent advancements involve monoclonal antibody-based tumor markers.
Purpose:
- To overcome the limitations of serum-based tumor marker assays for early cancer diagnosis.
- To explore novel tumor markers and enhance existing assay systems.
- To investigate the combination of multiple tumor markers for improved diagnostic accuracy.
Summary:
- Tumor marker research has evolved significantly since the discovery of Bence Jones protein.
- Despite advancements like alpha-fetoprotein and monoclonal antibody-based markers, early cancer diagnosis remains challenging.
- Ongoing efforts focus on developing new markers, refining assay technologies, and utilizing combined marker strategies.
Impact:
- Improved early detection of cancer and precancerous conditions.
- Potential for more effective cancer screening and patient monitoring.
- Advancement of diagnostic tools in oncology.