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A strategy for improving the sensitivity of molecularly imprinted electrochemical sensors based on catalytic copper
Jianping Li1, Yijuan Shao1, Weiling Yin1
1College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, China.
Abstract:
A novel method to improve the sensitivity of molecularly imprinted polymer sensors was developed. Oxytetracycline (OTC), which was selected as the template molecule, was first rebound to the imprinted cavities. Gold nanoparticles were then labeled with the amino groups of OTC molecules via electrostatic adsorption and non-covalent interactions. Copper ions were catalytically reduced by the gold nanoparticles, and copper was deposited onto the electrode. The deposited copper was electrochemically dissolved, and its oxidative currents were recorded by differential pulse voltammetry (DPV). OTC could be determined indirectly within the concentration range of 3.0×10(-10) to 1.5×10(-7)mol L(-1) with a detection limit of 6.8×10(-11)mol L(-1).
