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Improved utilization of ADAS-cog assessment data through item response theory based pharmacometric modeling

Sebastian Ueckert1, Elodie L Plan, Kaori Ito

  • 1Pharmacometrics Research Group Department of Pharmaceutical Biosciences, Uppsala University, P.O. Box 591, SE-751 24, Uppsala, Sweden, sebastian.ueckert@farmbio.uu.se.

Pharmaceutical Research
|March 6, 2014
PubMed
Summary

This study enhances Alzheimer's disease (AD) trial analysis by combining item response theory (IRT) and pharmacometric modeling. This approach offers a more powerful and precise method for utilizing ADAS-cog data compared to traditional scoring.

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