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Mango peel pectin as a carrier for solid dispersions.

Shobhit Kumar1, Satish Kumar Gupta1

  • 1Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut, India.

Polimery W Medycynie
|March 6, 2014
PubMed
Summary
This summary is machine-generated.

Pectin from mango peel was evaluated as a carrier for solid dispersions. While it showed a slower drug release compared to lactose, its properties suggest potential use in solid dispersion formulations.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Solid dispersions are a strategy to enhance drug solubility and dissolution.
  • Pectin, a natural polysaccharide, possesses unique physicochemical properties.
  • Investigating novel natural carriers is crucial for pharmaceutical formulation development.

Purpose of the Study:

  • To evaluate pectin, extracted from mango peel, as a carrier material for pharmaceutical solid dispersions.
  • To assess the impact of pectin on the dissolution rate of a model drug.

Main Methods:

  • Extraction of pectin from mango peel.
  • Preparation of solid dispersions using pectin and aceclofenac as the model drug.
  • Comparative dissolution studies of pectin-based solid dispersions versus a control (lactose).

Main Results:

  • Pectin-based solid dispersions exhibited a slower release rate of aceclofenac compared to lactose-based solid dispersions over a specific time period.
  • The observed slower release is attributed to pectin's aqueous solubility and swelling characteristics.

Conclusions:

  • Pectin demonstrates potential as a carrier for solid dispersions, despite influencing drug release kinetics.
  • Its swelling capacity and solubility profile warrant further investigation for controlled drug release applications.
  • Mango peel pectin offers a sustainable source for pharmaceutical excipient development.