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Updated: May 2, 2026
Isolation of Human Endometrial Stromal Cells for In Vitro Decidualization
Published on: September 1, 2018
In vitro effect of danazol on endometrioma cells in culture
Beth Ann Ollivierre1, Violeta Cuenca1, Lydia Kaufman1
1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Upstate Medical University, Syracuse, New York, USA.
Objective:
To evaluate the effect of danazol on endometrioma cells in culture, in relation to cell proliferation.
Study Design:
Danazol has been shown to be effective in treating endometriosis, leading to remission. The mode of action is through suppression of gonadotropins. A direct effect on endometriosis implants has been suggested. This study was conducted on endometrioma cell lines using various concentrations of danazol in ethanol solution.
Results:
Danazol showed a decrease in proliferation ofendometrioma cells in culture. This was also associated with an increase in apoptosis and necrosis ofcultured cells.
Conclusion:
This study demonstrates the direct effect of danazol on endometrioma cells in culture.
