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Related Concept Videos

Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

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Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
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Delivery Pathways to the Lysosome01:36

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Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
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Phagocytosis00:41

Phagocytosis

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Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis ("cellular eating") is one of three major types of endocytosis. Cells use phagocytosis to take in large objects, such as other cells (or their debris), bacteria, and even viruses.
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Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis (“cellular eating”) is one of three major types of endocytosis. Cells use phagocytosis to take in large objects—such as other cells (or their debris), bacteria, and even viruses.
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Autophagy01:27

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Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
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Endocytosis01:16

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Eukaryotic cells acquire nutrients for growth and proliferation. Nutrients and other molecules that require degradation are internalized from the extracellular space by a process called endocytosis. The term ‘endocytosis' was first coined by Christian de Duve in 1963.
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Updated: May 2, 2026

Exploring the Sequential Cellular Events of Phagocytosis Triggered by Godanti Bhasma in Mammalian Cells
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Angiophagy: clearing or clogging microvessels?

Costantino Iadecola1

  • 1Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY 10021, USA.

Science Translational Medicine
|March 7, 2014
PubMed
Summary
This summary is machine-generated.

The body naturally clears small blood clots using angiophagy. This discovery offers new therapeutic strategies for treating microvascular occlusive diseases in the brain and heart.

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Area of Science:

  • Biomedical Science
  • Vascular Biology
  • Pathology

Background:

  • Microvascular occlusive diseases, affecting the brain and heart, pose significant health challenges.
  • Current treatments for these conditions are limited, necessitating novel therapeutic approaches.

Purpose of the Study:

  • To elucidate the physiological mechanisms by which the body clears small blood clots.
  • To explore the potential of leveraging these natural processes for treating microvascular occlusive diseases.

Main Methods:

  • The study investigated the cellular and molecular processes involved in clot resolution within blood vessels.
  • Experimental models were used to observe and analyze the body's response to microvascular occlusions.

Main Results:

  • A natural process termed 'angiophagy' was identified, where the body actively clears small vascular clots.
  • Angiophagy demonstrates a significant role in maintaining microvascular patency.

Conclusions:

  • Angiophagy represents a key endogenous mechanism for clearing small blood clots.
  • Harnessing angiophagy presents a promising new avenue for developing treatments for cerebral and cardiac microvascular occlusive diseases.