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Tumor necrosis factor induces acute phase proteins in rats
I Gresser1, F Delers, N Tran Quangs
1Lab. Viral Oncology, CNRS, Villejuif, France.
Journal of Biological Regulators and Homeostatic Agents
|October 1, 1987
Summary
Tumor necrosis factor (TNF) significantly elevates acute phase proteins in rats, suggesting its crucial role in inflammation. This finding highlights TNF
Area of Science:
- Immunology
- Biochemistry
Background:
- Tumor necrosis factor (TNF) is a key cytokine involved in immune responses.
- The acute phase response is a systemic reaction to inflammation.
Purpose of the Study:
- To investigate the effect of recombinant mouse TNF on acute phase protein levels in vivo.
- To explore the role of TNF in the inflammatory response.
Main Methods:
- WAG rats were inoculated with recombinant mouse TNF.
- Serum and plasma levels of acute phase proteins were measured.
Main Results:
- A rapid and marked increase in serum haptoglobin, alpha 1 acid glycoprotein, and alpha 2 macroglobulin was observed.
- Plasma fibrinogen levels also showed a significant increase.
Conclusions:
- TNF administration induces a robust acute phase protein response in rats.
- These findings support a significant role for TNF in mediating the inflammatory response in vivo.
- TNF may contribute to the pathogenesis of inflammatory disorders.