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Transforming growth factor beta in the control of epidermal proliferation
J A Barnard1, C C Bascom, R M Lyons
1Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232.
The American Journal of the Medical Sciences
|September 1, 1988
Abstract:
Transforming growth factor beta is a polypeptide growth factor with a multiplicity of diverse biologic effects. Increasingly, data support a role for TGF beta in the autocrine regulation of normal epithelial cell growth (Figure 1). Definition of the normal pathways for growth stimulation and inhibition of epithelial cell growth by autocrine peptides like TGF beta and TGF alpha undoubtedly will increase understanding of normal growth and development, embryogenesis, wound repair, and tumorigenesis.