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Optimisation of reconstruction--reprojection-based motion correction for cardiac SPECT.

Tuija S Kangasmaa¹, Antti O Sohlberg

¹Department of Radiation Therapy, Vaasa Central Hospital, Hietalahdenkatu 2-4, 65130, Vaasa, Finland, tuija.kangasmaa@vshp.fi.

Annals of Nuclear Medicine

|March 7, 2014

Summary

Optimizing cardiac motion correction in myocardial perfusion SPECT using reconstruction-reprojection methods improves image quality. Mutual information and three iterations offer effective motion correction for clinical use.

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Area of Science:

Nuclear Medicine
Medical Imaging
Cardiology

Background:

Cardiac motion significantly degrades myocardial perfusion SPECT images, causing artifacts.
Reconstruction-reprojection algorithms are effective for automatic motion correction.
Previous methods lacked full optimization of parameters and implementation details.

Purpose of the Study:

To optimize and compare two reconstruction-reprojection based motion correction techniques for myocardial perfusion SPECT.
To evaluate the impact of different cost functions and iteration numbers on motion correction accuracy and efficiency.

Main Methods:

Two methods were compared: Method 1 (projection space correction) and Method 2 (reconstruction space correction).
Optimized parameters included cost functions (squared difference, normalized cross-correlation, mutual information) and iteration count.

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Methods were tested on simulated cardiac perfusion SPECT data with added lateral shift, vertical shift, and vertical creep.

Main Results:

Method 2 showed slightly better overall performance but had significantly longer execution times than Method 1.
Mutual information consistently yielded the best results across all motion types and methods.
Three iterations were sufficient for Method 1 to achieve good quality correction.

Conclusions:

The traditional reconstruction-reprojection method (Method 1) with mutual information and three iterations is a clinically viable option for myocardial perfusion SPECT motion correction.
While reconstruction-space correction (Method 2) offers marginal benefits, its computational cost limits its clinical applicability.