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Multicenter evaluation of single-photon emission computed tomography quantification with third-party reconstruction

Tuija S Kangasmaa1, Chris Constable, Eero Hippeläinen

  • 1aDepartment of Radiation Therapy, Vaasa Central Hospital, Vaasa bHUS Medical Imaging Center, Helsinki University Central Hospital, Helsinki cLaboratory of Clinical Physiology and Nuclear Medicine, Joint Authority for Päijät-Häme Social and Health Care, Lahti, Finland dHERMES Medical Solutions, Stockholm, Sweden.

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Summary

Quantitative single-photon emission computed tomography (SPECT) is now reproducible across multiple centers. Novel reconstruction software demonstrates reliable SPECT quantification, crucial for clinical applications.

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Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Quantitative Analysis

Background:

  • Single-photon emission computed tomography (SPECT) was historically not considered quantitative.
  • Recent advancements in reconstruction algorithms have enabled quantitative SPECT imaging.
  • Reproducibility is critical for the clinical adoption of quantitative SPECT.

Purpose of the Study:

  • To evaluate the reproducibility of quantitative SPECT.
  • To assess the performance of novel third-party reconstruction software.
  • To investigate multicenter SPECT quantification using phantoms.

Main Methods:

  • Phantom studies were conducted across five hospitals using eight SPECT scanners (GE and Siemens).
  • A Jaszczak phantom determined conversion factors; a NEMA-IEC phantom assessed quantitative accuracy with spherical inserts.
  • Reconstruction was centralized using HERMES HybridRecon with corrections for attenuation, scatter, and collimator-detector response.

Main Results:

  • The coefficient of variation (CoV) for recovery coefficients in the NEMA-IEC phantom ranged from approximately 19% to 5%, improving with larger sphere diameters.
  • Intersite CoV was comparable to intrasite CoV, indicating consistent performance across different centers and scanners.
  • Quantitative SPECT demonstrated high reproducibility in a multicenter setting.

Conclusions:

  • Quantitative SPECT is a reproducible imaging modality in a multicenter environment.
  • Third-party reconstruction software can achieve reliable SPECT quantification.
  • These findings support the clinical utility of quantitative SPECT.