Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple sclerosis: involvement of interferons in lesion pathogenesis.

U Traugott1, P Lebon

  • 1Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461.

Annals of Neurology
|August 1, 1988
PubMed
Summary

Interferons (IFNs) are present in active multiple sclerosis lesions, particularly IFN-gamma on astrocytes, suggesting a role in lesion growth. Other IFNs may have local immunosuppressive effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Measles Sclerosing Subacute PanEncephalitis (SSPE), an intriguing and ever-present disease: Data, Assumptions and new Perspectives" [Rev. Neurol. 177 (2021) 1059-68].

Revue neurologique·2022
Same author

Measles Sclerosing Subacute PanEncephalitis (SSPE), an intriguing and ever-present disease: Data, assumptions and new perspectives.

Revue neurologique·2021
Same author

Unusual cause of dyspnea: Cardiac fusiform cells carcinoma.

Annales de cardiologie et d'angeiologie·2020
Same author

Clinical severity and molecular characteristics of circulating and emerging rotaviruses in young children attending hospital emergency departments in France.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2016
Same author

Markers of a recent bocavirus infection in children with Kawasaki disease: "a year prospective study".

Pathologie-biologie·2014
Same author

Low immunogenicity of seasonal trivalent influenza vaccine among patients receiving docetaxel for a solid tumour: results of a prospective pilot study.

British journal of cancer·2011

Area of Science:

  • Neuroimmunology
  • Cellular Biology

Background:

  • Interferons (IFNs) are crucial signaling proteins with diverse immune functions.
  • Multiple Sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system.

Purpose of the Study:

  • To investigate the presence and distribution of Interferon-alpha (IFN-α), Interferon-beta (IFN-β), and Interferon-gamma (IFN-γ) in central nervous system lesions of Multiple Sclerosis (MS) patients.
  • To correlate IFN presence with lesion activity, astrocyte expression of major histocompatibility complex (MHC) antigens, and cellular infiltrate composition.

Main Methods:

  • Immunocytochemical staining of central nervous system tissue from MS patients and controls.
  • Utilized monoclonal antibodies and polyclonal antisera for IFN-α, IFN-β, and IFN-γ detection.
  • Correlated IFN distribution with lesion activity, MHC class I and II antigen expression on astrocytes, and cellular infiltrates.

Related Experiment Videos

Main Results:

  • IFNs were detected in active MS lesions but not in inactive ones.
  • Acute MS plaques showed widespread IFN distribution on glial and infiltrating cells.
  • In active chronic MS, IFNs were concentrated at lesion edges; IFN-γ was most common on astrocytes, IFN-α on macrophages, and IFN-β on both.
  • IFNs were rare in normal white matter and gliotic centers.
  • Astrocyte MHC antigen distribution mirrored IFN-γ and IFN-β patterns.

Conclusions:

  • IFN-γ may contribute to active lesion expansion in MS.
  • IFN-α and IFN-β might exert localized immunosuppressive effects within MS lesions.