Histomorphometric evaluation of a calcium-phosphosilicate putty bone substitute in extraction sockets

Area of Science:

• Biomaterials Science
• Oral and Maxillofacial Surgery
• Regenerative Medicine

Background:

• Extraction sockets present a challenge for maintaining alveolar bone volume.
• Alloplastic bone substitutes are utilized to promote bone regeneration in these defects.
• Calcium phosphosilicate putty is a synthetic bone graft material with osteoconductive properties.

Purpose of the Study:

• To evaluate the efficacy of calcium phosphosilicate putty in promoting bone regeneration within extraction sockets.
• To histomorphometrically and radiographically assess the new bone formation and graft resorption over time.

Main Methods:

• Twenty-four extraction sockets were grafted with calcium phosphosilicate putty.
• Radiographic analysis was performed to assess tissue radiopacity.
• Histomorphometric analysis of bone cores from 17 sockets was conducted at 5-6 months post-grafting.

Main Results:

• Radiographic analysis confirmed the presence of radiopaque tissue in all grafted sockets.
• Histomorphometry revealed a mean vital bone content of 31.76% (± 14.20%).
• A mean residual graft content of 11.47% (± 8.99%) was observed after a mean healing period of 5.7 months.

Conclusions:

• Calcium phosphosilicate putty facilitates significant vital bone formation in extraction sockets.
• The observed resorption rate of the putty is timely, supporting its clinical application.
• This alloplastic bone substitute is a reliable option for osseous regeneration in post-extraction defects.