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Gastrointestinal morbidity in obesity
Andres Acosta1, Michael Camilleri
1Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Annals of the New York Academy of Sciences
|March 8, 2014
Summary
Obesity involves complex gastrointestinal (GI) factors affecting caloric balance. This study assesses the GI system's role in obesity and related GI diseases, clarifying cause and effect.
Area of Science:
- Gastroenterology and Metabolic Diseases
Background:
- Obesity is a complex condition driven by energy imbalance, with the gastrointestinal system playing a crucial role.
- Gastrointestinal hormones and intake regulation mechanisms are altered in obesity, contributing to weight gain.
- The exact causal relationship between the GI system and obesity remains unclear.
Purpose of the Study:
- To evaluate the specific role of each gastrointestinal organ in the development of obesity.
- To investigate the gastrointestinal morbidity associated with obesity across various GI organs.
Main Methods:
- Review of existing literature on obesity and gastrointestinal function.
- Analysis of the relationship between body weight, abdominal adiposity, and specific GI disorders.
Main Results:
- Obesity is linked to significant gastrointestinal morbidity, including gastroesophageal reflux disease, cholelithiasis, and nonalcoholic steatohepatitis.
- These GI conditions often manifest earlier and are more prevalent in individuals with obesity compared to type 2 diabetes mellitus and cardiovascular disease.
Conclusions:
- The gastrointestinal system is integral to obesity pathogenesis and is significantly impacted by the condition.
- Understanding the bidirectional relationship between obesity and GI health is crucial for managing metabolic and digestive diseases.
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