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Published on: May 31, 2016
Subthalamic deep brain stimulation effects on odor identification in Parkinson's disease
M Fabbri1, L C Guedes, M Coelho
1IRCCS Institute of Neurological Science, Bologna, Italy; Clinical Pharmacology Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal.
Background And Purpose:
Olfactory dysfunction is common in Parkinson's disease (PD) and it is one of the earliest non-motor symptoms. A few studies have suggested that deep brain stimulation of the subthalamic nucleus (STN-DBS) could improve olfactory function. Our aim was to evaluate the acute effect of bilateral STN-DBS on a commonly used smell test in PD patients.
Methods:
Fifteen PD patients who underwent bilateral STN-DBS and 15 controls were recruited. Patients and controls were tested for odor identification.
Results:
No statistical differences were documented between ON and OFF STN-DBS acute stimulation concerning olfaction. Controls presented a better performance for olfactory identification than patients.
Conclusions:
Our exploratory study did not support that bilateral STN-DBS could have an acute effect on olfactory function in PD patients.
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