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Updated: May 2, 2026

Generation of Human CD40-activated B cells
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Targeting human CD27 with an agonist antibody stimulates T-cell activation and antitumor immunity

Lawrence J Thomas1, Li-Zhen He2, Henry Marsh1

  • 1Celldex Therapeutics, Inc.; Needham, MA USA.

Oncoimmunology
|March 8, 2014
PubMed

CD27 is an important co-stimulatory receptor of T cells that can potentially be exploited for immunotherapy. We developed a human IgG1 antibody that targets human CD27, and demonstrated its immunostimulatory and antineoplastic activity in various preclinical models. Currently, the antibody (1F5, CDX-1127) is being tested in patients affected by advanced malignancies.

Keywords:
CD27Fc receptorsco-stimulationimmunotherapymonoclonal antibody

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