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Identification of a second interferon-regulated murine Mx gene

P Staeheli1, J G Sutcliffe

  • 1Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037.

Molecular and Cellular Biology
|October 1, 1988
PubMed
Summary

Researchers identified a second mouse Mx gene (Mx2) involved in influenza virus resistance. While similar to Mx1, Mx2 transcripts in resistant strains showed mutations, suggesting a complex genetic basis for viral immunity.

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Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
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