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Combating the rise of antibiotic resistance in children
G Nicolini1, F Sperotto, S Esposito
1Pediatric Unit, Ospedale San Martino Belluno, Italy - susanna.esposito@unimi.it.
Insights
Pediatric antibiotic use is rising, increasing resistant bacteria. This review highlights antibiotic misuse in children and proposes strategies like antibiotic stewardship programs and updated guidelines to combat antimicrobial resistance.
Area of Science:
- Pediatrics
- Infectious Diseases
- Pharmacology
Background:
- Antibiotics are crucial for treating bacterial infections in children, who receive them more frequently than other medications.
- Improper and excessive antibiotic use has led to a significant increase in resistant bacterial strains.
- A lack of pediatric-specific clinical trials has resulted in limited high-evidence knowledge regarding antibiotic efficacy and safety in children.
Purpose of the Study:
- To review current antibiotic usage patterns in pediatrics.
- To highlight the challenges and problems associated with increasing antimicrobial resistance in pediatric populations.
- To suggest effective strategies for reducing the emergence and spread of antibiotic resistance.
Main Methods:
- This study is a review of existing literature on antibiotic use in pediatrics.
- It synthesizes information on antibiotic misuse and its link to antimicrobial resistance.
- It proposes potential solutions and interventions based on current knowledge.
Main Results:
- The review identifies significant issues with antibiotic misuse in pediatric care.
- It underscores the growing threat of antimicrobial-resistant bacterial strains due to this misuse.
- Several strategies are proposed to mitigate the problem, including enhanced antibiotic stewardship.
Conclusions:
- Antibiotic stewardship programs are essential for containing antimicrobial resistance and should be implemented widely.
- Updating guidelines for existing antibiotics is crucial to prevent misuse.
- Educational initiatives and online tools can improve knowledge and promote appropriate antibiotic use in pediatrics.
Abstract:
Antibiotics are a cornerstone to treat bacterial infections and children received more frequently these drugs than any other class of medication. However, the improper and excessive use of antibiotics in the past decades has increased the emergence of resistant bacterial strains. Moreover, the lack of specific pediatric clinical trials on antibiotics led to a scarcity of high-evidence-level knowledge. The problem of the increase in antibiotic resistance should be known by all medical figures and probably by all members of the society, and a plan for an efficient strategy to improve antibiotic use in the entire world is highly needed. This review summarizes how antibiotics are mainly used in pediatrics and highlights the main problems related to the increase of antimicrobial-resistant bacterial strains, suggesting possible methods for reducing this increase. An excellent instrument to contain the emergence of antimicrobial resistance appeared the antibiotic stewardship program, that should be proposed and actualized in all contests in which antibiotics use is a common practice. Targeting the existing antibiotics with specific updated guidelines is also an essential measure to avoid antibiotics misuse. Moreover, educational on-line tools and their diffusions are useful strategies to diffuse knowledge on when and how to use antibiotics.
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