Related Experiment Video

Updated: May 2, 2026

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.7K

Association between serum total antioxidant status and coronary microvascular function in idiopathic dilated

M Caliskan1, H Gullu, D Erdogan

  • 1Department of Cardiology, Baskent University, Konya Teaching and Medical Research Center, Hoca Cihan Mah., Saray Cad., No:1, Selcuklu, Konya, Turkey, caliskandr@gmail.com.

Herz
|March 11, 2014
PubMed

Insights

Idiopathic dilated cardiomyopathy (IDC) is linked to impaired coronary microvascular function, indicated by reduced coronary flow reserve (CFR). Increased inflammatory markers like hsCRP correlate with this dysfunction in IDC patients.

Area of Science:

  • Cardiology
  • Biomedical Science
  • Internal Medicine

Background:

  • Coronary microvascular impairment is a potential cause of myocardial ischemia and systolic dysfunction in patients with idiopathic dilated cardiomyopathy (IDC).
  • Understanding the relationship between inflammatory markers and microvascular function in IDC is crucial for patient management.

Purpose of the Study:

  • To investigate the association between serum inflammatory markers, total antioxidant status (TAS), and coronary flow reserve (CFR) in patients with IDC.
  • To evaluate coronary microvascular function in IDC patients compared to healthy controls.

Main Methods:

  • The study enrolled 41 patients with IDC and 33 healthy controls.
  • Serum levels of high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and TAS were measured.
  • Coronary flow reserve (CFR) was assessed using echocardiography.

Main Results:

  • Patients with IDC exhibited significantly higher hsCRP levels and lower TAS and CFR compared to controls.
  • Lower CFR (<2) in IDC patients was associated with significantly higher hsCRP, TNF-α, and IL-6 levels, and lower TAS.
  • CFR showed significant correlations with hsCRP, TAS, red cell distribution width (RDW), IL-6, and TNF-α.

Conclusions:

  • Plasma proinflammatory cytokine levels and hsCRP are elevated in patients with IDC.
  • Impaired CFR in IDC patients reflects coronary microvascular dysfunction, associated with increased inflammatory markers.
Abstract

More Related Videos

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations08:21

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

2.0K
Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction08:35

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

3.1K

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
790
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.8K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
1.1K
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
495