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Predicting onset of chronic lung disease using cord blood cytokines

Daishi Takao1, Satoshi Ibara, Takuya Tokuhisa

  • 1Division of Pediatrics, Maternal and Perinatal Care Center, Aizenbashi Hospital, Osaka, Japan.

Pediatrics International : Official Journal of the Japan Pediatric Society
|March 12, 2014
PubMed

Insights

Cord blood interleukin-6 (IL-6) and interleukin-8 (IL-8) can predict chronic lung disease (CLD) in infants with intrauterine infection. Higher levels of these cytokines in newborns indicate a greater risk of developing CLD.

Area of Science:

  • Neonatal Medicine
  • Immunology
  • Respiratory Medicine

Background:

  • Intrauterine infection poses a risk for neonatal chronic lung disease (CLD).
  • Early prediction of CLD is crucial for timely intervention in high-risk infants.
  • Cord blood cytokine levels are being investigated as potential biomarkers.

Purpose of the Study:

  • To evaluate the applicability of cord blood interleukin-6 (IL-6) and interleukin-8 (IL-8) as early predictors of CLD onset.
  • To compare IL-6 and IL-8 levels in infants with and without CLD following intrauterine infection.

Main Methods:

  • Eighty very low-birthweight infants with chorioamnionitis were studied.
  • Infants were categorized into CLD (42) and non-CLD (38) groups.
  • Cord blood IL-6 and IL-8 levels were measured and compared between groups.

Main Results:

  • The CLD group exhibited significantly higher cord blood IL-6 and IL-8 levels (P < 0.01).
  • Higher IL-6 and IL-8 were associated with longer mechanical ventilation and hospitalization durations.
  • IL-6 cutoff of 48.0 pg/mL showed 76% sensitivity and 96% specificity; IL-8 cutoff of 66.0 pg/mL showed 71% sensitivity and 82% specificity for CLD prediction.

Conclusions:

  • Cord blood IL-6 and IL-8 levels are significantly elevated in infants who develop CLD.
  • Both IL-6 and IL-8 serve as valuable predictors for the early onset of CLD in this population.
Abstract

Keywords:
chorioamnionitischronic lung diseasecytokinesinflammationneonate

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