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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

112
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
112
Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.6K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.7K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.5K
Allergic Reactions02:06

Allergic Reactions

26.4K
Overview
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Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

280
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
280

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Related Experiment Video

Updated: May 2, 2026

Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10
10:42

Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10

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Allergens, germs and asthma.

Glenis Kathleen Scadding1

  • 1RNTNE Hospital, London, UK.

The Clinical Respiratory Journal
|March 12, 2014
PubMed
Summary

Most asthma cases originate in the nose, involving allergies and both viral and bacterial infections. This understanding of asthma pathogenesis opens new therapeutic avenues by targeting atopy and infection.

Area of Science:

  • Immunology
  • Respiratory Medicine
  • Allergy

Background:

  • Asthma is a complex inflammatory condition of the airways.
  • Current understanding suggests asthma is more than isolated bronchial inflammation.

Purpose of the Study:

  • To investigate asthma pathogenesis by examining data from both upper and lower airways.
  • To integrate findings from genetic, molecular, histological, and clinical studies.

Main Methods:

  • Systematic review of high-quality, English-language studies published from 1990 onwards.
  • Inclusion of research on human asthma and nasal polyp subjects.

Main Results:

  • Asthma is a polymorphic disease, often involving more than just Th2 bronchial inflammation.
Keywords:
airway epitheliumasthmaasthma mechanismsbacterial infectionviral infection

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  • Viral infections can initiate asthma in children and adults, synergizing with atopy.
  • Chronic staphylococcal colonization may promote asthma, potentially facilitated by viral infections.

    • Conclusions:

    • Asthma frequently begins in the nasal passages, linked to allergies and infections (viral and bacterial).
    • The interplay of atopy and infection presents novel therapeutic strategies for asthma management.