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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Related Experiment Video

Updated: Sep 27, 2025

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
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Allergic Rhinitis in Childhood and the New EUFOREA Algorithm.

Glenis Kathleen Scadding1,2, Peter Kenneth Smith3, Michael Blaiss4

  • 1Ear, Nose and Throat Department, University College London Hospitals National Health Service Foundation Trust, London, United Kingdom.

Frontiers in Allergy
|April 7, 2022
PubMed
Summary

Childhood allergic rhinitis is frequently misdiagnosed, impacting quality of life and potentially leading to asthma. The new EUFOREA algorithm offers a comprehensive guide for effective management at all levels.

Keywords:
allergen specific immunotherapyantihistaminesasthmafixed dose combinationsintranasal corticosteroidspediatric allergic rhinitissleep

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Area of Science:

  • Pediatrics
  • Allergology
  • Immunology

Background:

  • Childhood allergic rhinitis is often overlooked, leading to undertreatment and significant negative impacts.
  • It is associated with numerous comorbidities, reduced quality of life, and impaired educational outcomes.
  • Untreated or poorly managed allergic rhinitis can exacerbate existing asthma or lead to its development.

Purpose of the Study:

  • To present an updated, expert-approved algorithm for the diagnosis and management of allergic rhinitis in children.
  • To provide a practical guide for healthcare professionals at all levels of care.
  • To consolidate current evidence and expert consensus into a usable clinical tool.

Main Methods:

  • Development of the EUFOREA (European Foundation for Allergy Research and Education) algorithm.
  • Incorporation of updated evidence and international expert consensus.
  • Adjustment and approval of the algorithm by a worldwide panel of experts.

Main Results:

  • The EUFOREA algorithm provides a succinct yet comprehensive guide for managing childhood allergic rhinitis.
  • It addresses diagnosis and treatment across various levels of healthcare.
  • The algorithm is based on updated evidence and global expert validation.

Conclusions:

  • Accurate diagnosis and effective management of childhood allergic rhinitis are crucial.
  • The EUFOREA algorithm serves as a valuable, updated resource for clinicians.
  • Implementation of this algorithm can improve patient outcomes and quality of life.