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Retinal vessel diameters decrease with macular ganglion cell layer thickness in autosomal dominant optic atrophy and

Cecilia Rönnbäck1, Karen Grønskov, Michael Larsen

  • 1Department of Ophthalmology, Glostrup Hospital, Glostrup, Denmark; Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

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Summary

Retinal arteries and veins are narrower in individuals with autosomal dominant optic atrophy (ADOA). This narrowing correlates with disease severity and ganglion cell loss, suggesting it’s a consequence, not a cause, of inner retinal atrophy.

Keywords:
autosomal dominant optic atrophydominant optic atrophyhypertensionretinal vessel diameters

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Area of Science:

  • Ophthalmology
  • Genetics
  • Vascular Biology

Background:

  • Autosomal dominant optic atrophy (ADOA) is a genetic disorder affecting the optic nerve.
  • The OPA1 gene is commonly implicated in ADOA.
  • Retinal vascular changes in ADOA are not well understood.

Purpose of the Study:

  • To compare retinal trunk vessel diameters in ADOA patients and healthy relatives.
  • To investigate the relationship between vessel caliber, disease severity, and retinal structure.

Main Methods:

  • Cross-sectional study of 52 ADOA patients and 55 healthy controls.
  • Retinal vessel diameters (CRAE, CRVE) measured from fundus photographs.
  • Statistical analysis adjusted for age, gender, refractive error, axial length, and MABP.

Main Results:

  • Retinal arteries and veins were significantly narrower in ADOA patients compared to controls.
  • Vessel narrowing (CRAE, CRVE) correlated with age and decreased visual acuity in ADOA.
  • CRAE reduction was associated with decreased macular ganglion cell-inner plexiform layer (GC-IPL) thickness in both groups.

Conclusions:

  • Narrower retinal vessels are associated with ADOA severity and ganglion cell loss.
  • These findings suggest that vascular narrowing is a consequence of inner retinal atrophy in ADOA.
  • Further longitudinal studies are required to confirm the causal relationship.