Role of selenium in male reproduction - a review

The role of Se and various selenoproteins in male reproductive performance is reviewed. Development of male reproductive tissue requires an optimal level of Se in testis, and a small deviation, either deficiency or excess, leads to abnormal development. Selenium is a constituent of selenoproteins including GPx1, GPx3, mGPx4, cGPx4, and GPx5 that protect against oxidative damage to spermatozoa throughout the process of sperm maturation, whereas selenoproteins, such as mGPx4 and snGPx4, serve as structural components of mature spermatozoa. Thus Se and selenoproteins ensure viability of spermatozoa as well as providing protection against reactive oxygen species. Gene knock-out studies of selenoproteins revealed that their absence during spermatogenesis results in abnormal spermatozoa, which in turn affects semen quality and fertility. Deviation from the optimal quantities of dietary Se, both above or below, may cause multiple abnormalities of spermatozoa and affect motility and fertility. Libido may also be increased by Se. Dietary Se should be in optimal quantity to maintain reproductive function in males and to avoid infertility.