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Aberrant resting-state functional connectivity in a genetic rat model of depression
Kathleen A Williams1, Neha S Mehta2, Eva E Redei2
1Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Psychiatry Research
|March 12, 2014
Abstract:
Abnormal intrinsic functional connectivity, measured by resting-state functional MRI, has been reported in major depressive disorder (MDD). Our study is the first to demonstrate hypo- and hyperconnectivity between the hippocampus and cortical, subcortical regions in a genetic animal model of depression, similar to connectivity anomalies found in MDD.
