Related Experiment Video
Updated: May 2, 2026
05:39
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
2.1K
[Adrenocortical carcinoma: Update in 2014].
Rossella Libé1, Guillaume Assié1
1Hôpital Cochin, service des maladies endocriniennes et métaboliques, centre de référence des cancers rares - COMETE-Cancer, 75014 Paris, France; Inserm U-1016, CNRS UMR8104, institut Cochin, université Paris-5, faculté de médecine Paris Descartes, 75006 Paris, France.
Presse Medicale (Paris, France : 1983)
|March 12, 2014
Summary
Atypical adrenal masses require investigation for adrenocortical cancer using advanced imaging. Complete surgical removal (R0) and multidisciplinary care are crucial for potentially curative treatment.
Area of Science:
- Endocrinology
- Oncology
- Radiology
- Nuclear Medicine
- Pathology
- Genetics
Context:
- Atypical adrenal masses necessitate thorough evaluation for potential adrenocortical cancer.
- Conventional imaging findings guide the characterization of adrenal masses.
Purpose:
- To outline the diagnostic and therapeutic strategies for adrenocortical cancer.
- To emphasize the importance of a multidisciplinary approach in managing this rare endocrine malignancy.
Summary:
- Advanced imaging techniques including CT with delayed contrast wash-out, MRI with chemical shift/wash-out analysis, and 18F-FDG PET aid in characterizing adrenal masses.
- Open adrenalectomy, aiming for complete resection (R0) without dissemination, is the primary curative treatment for resectable adrenocortical cancer.
- Management involves a collaborative effort among endocrinologists, oncologists, surgeons, radiologists, nuclear medicine specialists, pathologists, and geneticists.
Impact:
- Multidisciplinary care ensures optimal patient management and outcomes.
- Collaborative networks like COMETE and ENS@T advance clinical practice and research in adrenocortical cancer.
- Emerging molecular markers promise improved diagnostic and therapeutic approaches in routine clinical settings.
Related Concept Videos
01:19Cushing Syndrome II: Pathophysiology
24
Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features...
24
01:27Adrenal Gland Disorders
3.7K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
3.7K
01:26Cushing Syndrome I: Introduction
36
Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the...
36
01:17Anatomy of the Adrenal Glands
5.7K
The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
5.7K
02:57Targeted Cancer Therapies
7.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.0K
02:56Treatment Resistant Cancers
2.6K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
2.6K