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Updated: Aug 15, 2026
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Analyzing and Building Nucleic Acid Structures with 3DNA
Published on: April 26, 2013
Distance analysis and sequence properties of functional domains in nucleic acids and proteins
1National Cancer Institute, Laboratory of Mathematical Biology, Frederick, MD 21701.
Gene Analysis Techniques
|September 1, 1988
Summary
We developed DISTANP, a new algorithm for analyzing distances between short sequences in nucleic acids and proteins. This tool helps differentiate functional domains by examining residue group distances.
Area of Science:
- Bioinformatics
- Computational Biology
- Sequence Analysis
Background:
- Analyzing sequence properties is crucial for understanding nucleic acid and protein function.
- Existing methods may lack the flexibility to analyze complex residue groupings.
Purpose of the Study:
- To present DISTANP, a unified algorithm for analyzing distances between short oligomers in large sequence collections.
- To extend existing DISTAN methodology for analyzing distances between groups of residues.
Main Methods:
- Development of the DISTANP algorithm.
- Application to analyze distances between oligomers and residue groups in nucleic acid and protein sequences.
Main Results:
- DISTANP enables analysis of distances between selected oligomer pairs.
- The algorithm allows for analysis of distances between defined groups of residues (e.g., acidic, hydrophobic).
- This facilitates the differentiation of sequence properties in functional domains.
Conclusions:
- DISTANP provides a unified and extended approach for sequence analysis.
- The method enhances the ability to characterize functional domains in nucleic acids and proteins.
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