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Updated: May 2, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Diffusion Tensor Imaging findings and their implications in schizophrenia.

Marek Kubicki¹, Martha E Shenton

¹aPsychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston bVeterans Affairs (VA) Boston Healthcare System, Brockton, Massachusetts, USA.

Current Opinion in Psychiatry

|March 12, 2014

Summary

This summary is machine-generated.

Recent research shows white matter changes in schizophrenia may occur before illness onset and potentially indicate risk. These findings offer new avenues for developing targeted treatments for this complex brain disorder.

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Area of Science:

Neuroscience
Psychiatry
Radiology

Background:

Schizophrenia is a complex brain disorder characterized by abnormal connectivity.
Diffusion Tensor Imaging (DTI) is a key technique for in vivo white matter investigation.

Purpose of the Study:

To review recent studies (last year) on white matter changes in schizophrenia.
To understand how white matter alterations impact treatment strategies.

Main Methods:

Review of high-impact studies published within the last year.
Focus on Diffusion Tensor Imaging research related to schizophrenia.

Main Results:

White matter changes are observed at or before schizophrenia onset, acting as a risk factor.
Some evidence suggests white matter changes may not progress without treatment.
Genetic and clinical risk factors are linked to distinct white matter alterations, potentially inflammatory or related to glial cell integrity.

Conclusions:

Recent findings propose novel hypotheses on schizophrenia pathophysiology involving white matter.
Further research with larger samples may pave the way for new therapeutic interventions.