Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Human interferon in viral diseases.

S B Greenberg¹

¹Department of Medicine, Baylor College of Medicine, Houston, Texas.

Infectious Disease Clinics of North America

|June 1, 1987

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Increasing Rates of Esophageal Stricture and Dilation Over 2 Decades in Eosinophilic Esophagitis.

Gastro hep advances·2023

Same author

A new SFAR/APSF collaboration: Another step towards the common goal of patient safety.

Anaesthesia, critical care & pain medicine·2019

Same author

Hyperinflation of the left anterior basal segment: a new sign of pectus excavatum severity on CT.

Clinical radiology·2017

Same author

Effect of ventilation on cerebral oxygenation in patients undergoing surgery in the beach chair position: a randomized controlled trial.

British journal of anaesthesia·2014

Same author

A dual contrast injection technique for multidetector computed tomography angiography of Fontan procedures.

The international journal of cardiovascular imaging·2007

Same author

Diaphragmatic hernia.

Pediatric cardiology·2003

Same journal

Prevention and Control of Clostridioides difficile Infection for the Infectious Diseases Clinician.

Infectious disease clinics of North America·2026

Same journal

Infection Control Strategies to Prevent Emergence and Transmission of Resistant Gram-Negative Bacteria.

Infectious disease clinics of North America·2026

Same journal

Preventing the Spread of Tuberculosis in Health Care Settings.

Infectious disease clinics of North America·2026

Same journal

Threats to Success: Principles of Infection Prevention and Control in Health Care Settings, Part 2: Device and Pathogen Management.

Infectious disease clinics of North America·2026

Same journal

Ventilator-Associated Events: Surveillance and Prevention.

Infectious disease clinics of North America·2026

Same journal

Nosocomial Fungal Infections: Epidemiology, Control Strategies, and Prevention of Candida and Other Yeasts.

Infectious disease clinics of North America·2026

See all related articles

Interferons show promise for viral infections like colds and herpes, but toxicity concerns and a lack of controlled studies limit their use. Further research is needed to understand interferon toxicity and optimize treatment strategies.

Area of Science:

Immunology
Virology
Pharmacology

Background:

Interferons (IFN) are studied for viral infections.
Clinical trials show IFN efficacy for rhinovirus, herpetic keratitis, condyloma acuminata, and laryngeal papillomatosis.
Limited controlled studies (40%) exist for IFN research.

Purpose of the Study:

To review the clinical efficacy and toxicity of interferons.
To assess the current state of interferon research and identify future directions.

Main Methods:

Review of published clinical studies on interferons.
Analysis of interferon efficacy and toxicity data.
Evaluation of study control and methodological rigor.

Main Results:

Related Experiment Videos

Significant clinical responses observed in specific viral infections.
High toxicity and a narrow therapeutic-to-toxic ratio (close to one) for human (HuIFN) and recombinant (rIFN) preparations.
Concerns regarding the control and rigor of published interferon studies.

Conclusions:

Interferons have demonstrated therapeutic potential but face challenges due to toxicity.
Further research is essential to elucidate mechanisms of toxicity and conduct well-controlled clinical trials.
Despite 30 years of research, the full potential and application of interferons remain to be explored.